0 - 4 C for short term (days to weeks), or -20 C for long term (months). Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . Review. refillable drug delivery devices and methods of use thereof: : ep15773877.4: : 2015-04-06: (): ep3125866a1: () Eltrombopag and Impurities Molecular Formula C29H36N6O6 Molecular Weight 564.64 Price Inquiry Product Description Eltrombopag is a is an agonist of the c-mpl (TpoR) receptor used as treatment for thrombocytopenia.It has been developed for certain conditions that lead to thrombocytopenia (abnormally low platelet counts). 2015 Apr;75(5):525-31. doi: 10.1007/s40265-015-0363-4. 442.48. UGT1A1 and UGT1A3 are responsible for the glucuronidation of eltrombopag. Stock Solution Storage: Epub 2013 Mar 4. Review. Annu Rev Med. It is not a substitute for medical advice. Important: The drug information on this page is meant to be educational. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Aug. 2013 Apr;24(3):284-96. doi: 10.1097/MBC.0b013e32835fac99. Review. 4: Desmond R, Townsley DM, Dunbar C, Young NS. Molecular Weight : 564.63: CAS Number : 496775-62-3: We will provide COA, HPLC, HNMR, MASS, MSDS with the purchase of Eltrombopag Olamine. Expert Opin Drug Metab Toxicol. Eltrombopag olamine | C29H36N6O6 | CID 135449331 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . Eltrombopag Olamine can be used for the research of cardiovascular. FDA label information for this drug is available at DailyMed. Review. Available from http://www.ncbi.nlm.nih.gov/books/NBK362529/ PubMed PMID: 27227203. MedKoo Cat#: 100941 Peak absorption of Eltrombopag occurs around 2-6 hours following oral administration, and the total oral absorption of drug-related material following a 75 mg dose was estimated to be at least 52%. what this drug is used for and how it is used. 2009;60:193-206. About 26-35 hours in patients with idiopathic thrombocytopenic purpura. PMID: 32804009. CAS NO: 496775-62-3 Molecular Formula: C 29 H 36 N 6 O 6 Molecular Weight: 564.633 EINECS NO: 629-876-8 MDL NO: MFCD22380664 Int J Mol Sci. Eur Rev Med Pharmacol Sci. 3: McCormack PL. Eltrombopag is eliminated primarily via the feces (59%), along with 31% being renally excreted. Review. PubMed PMID: 22054810. It [. Eltrombopag Olamine (Eltrombopag diethanolamine salt) is an orally active thrombopoietin receptor nonpeptide agonist. The metabolism of Acemetacin can be decreased when combined with Eltrombopag. Improve clinical decision support with information on. Eltrombopag, sold under the brand name Promacta among others, is a medication used to treat thrombocytopenia (abnormally low platelet counts) and severe aplastic anemia. Review. If you believe you are experiencing an interaction, contact a healthcare provider immediately. Epub 2014 Oct 31. Review. Find Clinical Trials for Eltrombopag Olamine - Check for trials from NCI's list of cancer clinical trials now accepting patients. J Hepatol. CAS Registry Number: 496775-62-3: Synonyms:;Eltrombopag Olamine [USAN];(1,1-Biphenyl)-3-carboxylic acid, 3-((2Z)-(1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5 . PubMed PMID: 23452139. what you should know about this drug before using it, other drugs that may interact with this drug, and. The molecular formula is. Please see your health care professional for more information about your specific medical condition and the use of this drug. M.W. 2010 Jul 21;4:139-45. Review. Eltrombopag: a review of its use in treatment-refractory chronic primary immune thrombocytopenia. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customers country. 2015 Jan;52(1):31-7. doi: 10.1053/j.seminhematol.2014.10.002. M.W. It may take up to 4 weeks before the medicine prevents major bleeding episodes. Reference standards of Eltrombopag Olamine API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below +91-172-5066494 (INDIA) +1-310-2949997 (USA) mktg@pharmaffiliates.com Chemical Formula: C29H36N6O6 Hot . . An oral, nonpeptide thrombopoietin receptor agonist. Therapeutic category Hematology . 15: Garnock-Jones KP. Eltrombopag is an orally bioavailable, small-molecule TPO-receptor agonist that interacts with the transmembrane domain of the human TPO-receptor. 1. This page contains information about Eltrombopag Olamine. Separate the administration of eltrombopag from food by at least 1 hour before and 2 hours after eating. The metabolism of Acetylsalicylic acid can be decreased when combined with Eltrombopag. C29H36N6O6. Eltrombopag in chronic hepatitis C. World J Gastroenterol. Related CAS #: Inhibitors/Agonists; Products. Molecular Formula C 25 H 22 N 4 O 4 .2 C 2 H 7 NO Molecular Weight 442.47 2 61.08 Catalogue Number AR-E01197 CAS Number 496775-62-3 Collections: ELTROMBOPAG Category: 496775-62-3, AR-E01197, C25H22N4O4 .2 C2H7NO, ELTROMBOPAG RELATED PRODUCTS C H 2 N O 4 532.60 AR-E01211 Add to Quote Eltrombopag's cell toxicity to five cancer cell lines and one macrophage cell line (4T1, A549, H1299, LLC, SMMC7721 and RAW264.7) was evaluated. 2020 Dec 24;22(1):97. doi: 10.3390/ijms22010097. Articles of Eltrombopag are included as well. ITP is a condition in which platelets are destroyed by the immune system. 2012 Jun 1;30(6):483-95. doi: 10.2165/11591550-000000000-00000. Eltrombopag Olamine: CAS Number: 496775-62-3: 1.2 Relevant identified uses of the substance or mixture and uses advised against; Identified uses: . Patients who carry this polymorphism in SERPINC1 are associated with antithrombin III deficiency and an increased risk of thromboembolism when treated with eltrombopag. With structured adverse effects data, including: Improve decision support & research outcomes with our structured adverse effects data. It is taken by mouth.. Eltrombopag was discovered as a result of research collaboration . 2015;16(14):2243-56. doi: 10.1517/14656566.2015.1085512. This information should not be interpreted without the help of a healthcare provider. Description: Short name. Expert Opin Pharmacother. Avoid multivalent ions. Epub 2020 Aug 17. E-481. Keep taking eltrombopag as directed and tell your doctor if you have any . This drug may be formulated in DMSO. In vitro studies suggest that CYP1A2 and CYP2C8 are responsible for the oxidative metabolism of eltrombopag. Customs Synonyms Chemsrc provides Eltrombopag (CAS#:496775-61-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Epub 2020 Aug 17. PubMed PMID: 24696622; PubMed Central PMCID: PMC3953736. 442.48 . PubMed PMID: 22480381. Name: Eltrombopag olamine CAS#: 496775-62-3 (olamine) Chemical Formula: C29H36N6O6 Exact Mass: Molecular Weight: 564.643 Elemental Analysis: C, 61.69; H, 6.43; N, 14.88; O, 17.00 Price and Availability Technical data Biological activity Solubility and formulation Protocols Calculators References 2: Merli P, Strocchio L, Vinti L, Palumbo G, Locatelli F. Eltrombopag for treatment of thrombocytopenia-associated disorders. Name Eltrombopag Olamine Molecular Formula C27H36N6O6 Molecular Weight 564.63 CAS Number (Or Caming Number for Non-CAS Products) 496775-62-3 Use Impurity of API Eltrombopag 3C and D). PubMed PMID: 25700916. Over the course of the experiment, eltrombopag was well tolerated, and no signs of acute toxicity were observed (Fig. Avoid life-threatening adverse drug events & improve clinical decision support. molecular weight [, Kuter DJ: The biology of thrombopoietin and thrombopoietin receptor agonists. 540Toronto, ON, M3J 0H1, 2022 Axios Research. Gene target. Eltrombopag Olamine is the orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. PROMACTA PROMACTA (eltrombopag) Tablets contain eltrombopag olamine, a small molecule thrombopoietin (TPO) receptor agonist for oral administration. Product Description: Blood Coagul Fibrinolysis. Zekry A, Freiman J: Eltrombopag: Is this "24 karat gold platelet" treatment for thrombocytopenia in cirrhosis associated with hepatitis C? ChemicalBull is a leading manufacturer and supplier of Eltrombopag Olamine in Gujarat. For cost-effective reason, minimum order of 1g is requested (typically very expensive). 2020 Dec 24;22(1):97. doi: 10.3390/ijms22010097. 2011 May;15 Suppl 1:23-32. doi: 10.3310/hta15suppl1/03. 8: Giannini EG, Afdhal NH. 2012 Jun;16(6):743-6. Review. Reference: Acta Pharm Sin B. Eltrombopag Olamine. Buy high quality Eltrombopag Olamine from SimSon Pharma Limited. 2014 Oct;74(16):1961-71. doi: 10.1007/s40265-014-0312-7. Epub 2011 Nov 4. Review. Eltrombopag may decrease the excretion rate of Abemaciclib which could result in a higher serum level. Each tablet. The chemical Eltrombopag olamine has a designated molecular formula of C29H36N6O6 and a molecular weight of 564.643 g/mol. Cancer Treat Res. :496775-62-3, MOQ 1 gram, Molecular Formula:,Molecular . Targets thrombopoietin receptor Solubility * Preparing Stock Solutions * The above data is based on the productmolecular weight 564.63. product Nevil G, Roth M, Gill J, Zhang W, Teicher B, Erickson SW, Gatto G, Smith M, Kolb EA, Gorlick R. Initial in vivo testing of TPO-receptor agonist eltrombopag in osteosarcoma patient-derived xenograft models by the pediatric preclinical testing consortium. This product has a molecular weight of g mol. PubMed PMID: 25578417; PubMed Central PMCID: PMC4293077. Pharmacotherapy. As shown in Fig. 2011 Jul 9;71(10):1333-53. doi: 10.2165/11207390-000000000-00000. . PMID: 33374151; PMCID: PMC7796119. Int J Technol Assess Health Care. : PA 32 22590 CAS : 376592-93-7 Molecular Formula : C13H11NO3 Molecular Weight : 229.23 In this, they differ from the previously discussed agents that act by attempting to curtail platelet destruction. [, Kim TO, Despotovic J, Lambert MP: Eltrombopag for use in children with immune thrombocytopenia. 13: Boyers D, Jia X, Jenkinson D, Mowatt G. Eltrombopag for the treatment of chronic immune or idiopathic thrombocytopenic purpura: a NICE single technology appraisal. InChI=1S/C25H22N4O4.2C2H7NO/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33;2*3-1-2-4/h4-13,26,30H,1-3H3,(H,32,33);2*4H,1-3H2/b27-22-;; bis(2-aminoethan-1-ol); 3'-{2-[(4Z)-1-(3,4-dimethylphenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-ylidene]hydrazin-1-yl}-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid, NCCO.NCCO.CC1=NN(C(=O)\C1=N/NC1=CC=CC(C2=CC=CC(=C2)C(O)=O)=C1O)C1=CC=C(C)C(C)=C1. See customer reviews, validations & product citations. Your child's dose needs may change if the child gains or loses weight. Powered by Shopify, 2-aminoethanol (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate, (Z)-2'-(benzyloxy)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-[1,1'-biphenyl]-3-carboxylic acid, (Z)-5'-chloro-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid, (2R,3R,4R,5S,6R)-6-((3'-((Z)-2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)-1-hydroxyhydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carbonyl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid, 3'-acetamido-2'-(((3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-[1,1'-biphenyl]-3-carboxylic acid, (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxylic acid, 1-(4-ethoxyphenyl)-5-(2-hydroxy-4-methoxybenzoyl)pyridin-2(1H)-one, (Z)-5'-chloro-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)-1-hydroxyhydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid, (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)-1-hydroxyhydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid, 5',5''-bis((Z)-2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-4'',6'-dihydroxy-[1,1':3',1'':3'',1'''-quaterphenyl]-3,3'''-dicarboxylic acid, (Z)-methyl 3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate, (Z)-ethyl 3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate, (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxamide, (2R,3R,4R,5S,6R)-6-((3-acetamido-3'-carboxy-[1,1'-biphenyl]-2-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid, (2R,3R,4R,5S,6R)-6-((3'-((Z)-2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carbonyl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid, (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid-13C4, (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid, Eltrombopag Related Compound (N-Acetyl -SB-611855 Glucuronide), Send us your request to receive a quotation.
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