442.47. Get updates, discounts and special offers. . * Please select Quantity before adding items. CAS number. AUC of eltrombopag is increased in patients with Asian ancestry (i.e., Japanese, Chinese, Taiwanese, Korean, or Thai); dosage adjustments recommended. The Eltrombopag antitumor effect on hepatocellular carcinoma. Pediatric patients 6 years of age: Initially, 50 mg once daily. TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc. ;IC50 Value: 0.27 uM (EC50 in murine BAF3 cells) [1];Target: thrombopoietin-receptor (c-mpl)Potential advantages of eltrombopag may include a sustained platelet response and a good tolerability profile. Patients with east Asian ancestry (e.g., Chinese, Japanese, Taiwanese, Korean, or Thai): Reduced initial dosages may be required (see Dosage under Dosage and Administration). Thanks, your subscription has been confirmed. Eltrombopag Olamine can induce apoptosis in hepatocellular carcinomab (HCC) as well[1][2][3][4][5]. Chemical Information. They are for reference only. It has the molecular formula C 25 H 22 N 4 O 4 2(C 2 H 7 NO). Eltrombopag (0.1 nM-10 M; 30 min) stimulates proliferation of BAF3/hTpoR cells[1]. Synonyms may include: SB 497115GR, UNII-4U07F515LG, Promacta, Revolade (ChemID). 2021 Feb 21. Eltrombopag olamine is a biphenyl hydrazone. Patent Use Code. (II) is marketed in USA by . Eltrombopag comes in two forms: oral tablet and oral suspension. Available for Android and iOS devices. DrugBank Accession Number. Eltrombopag olamine is a new, orally active thrombopoietin-receptor (c-mpl) agonist that stimulates thrombopoiesis. eltrombopag (as olamine) eltrombopag compd with 2-aminoethanol (1:2) eltrombopag compd with 2-aminoethanol (1:2) [mi] eltrombopag olamine [jan] eltrombopag olamine [mart.] Research use only, not for human use. Do not split, crush, or chew tablets and mix with food or liquids. Potential to inhibit CYP2C8 and CYP2C9, UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A9, UGT2B7, UGT2B15 and the organic anion-transporting polypeptide (OATP) 1B1 and breast cancer resistance protein (BCRP). J&H Chemical is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other . Eltrombopag (30 M; 120 min) activates p-STAT5 in megakaryocytes[1]. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin . UNII-4U07F515LG, Promacta, Revolade (ChemID). For research use only. Train patients or caregivers on proper dosing, preparation, and administration of the oral suspension. Do not use to normalize platelet counts because excessive increases in platelet count may increase the risk of thromboembolic complications. Exhibited dose-dependently antiapoptotic effects N2C-Tpo cells with a concentration over 0.03 M. Adjust the dosage in 50-mg increments every 2 weeks as necessary to achieve a target platelet count 50,000/mm3 (see Table 10). If patients achieve tri-lineage response, including transfusion independence, for at least 8 weeks, may reduce dosage of eltrombopag by 50%. . Repurposing Eltrombopag for Multidrug Resistant Staphylococcus aureus Infections. Increased risk of thrombosis or thromboembolism with high platelet counts resulting from excessive eltrombopag dosage. ATC class: B02BX05 Eltrombopag interacts with the transmembrane domain of the TPO receptor (also known as cMpl) leading to increased platelet production. Chemical Name. Filter by: Clear. For patients with Asian ancestry or hepatic impairment (mild, moderate, or severe), reduce initial dose of eltrombopag by 50%. ), Risk of serious and potentially life-threatening hepatotoxicity. We're doing our best to keep everyone healthy and safe in the workplace while also avoiding the interruptions to our day-to-day operations. Type of study: Fasting Design: Single-dose, two treatment, two-period, crossover in vivo . When used for the treatment of chronic hepatitis C-associated thrombocytopenia, monitor platelet counts every week prior to initiating antiviral therapy. Erickson-Miller CL, et al. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Promacta, prednisone, dexamethasone, triamcinolone, Decadron, Deltasone, Kenalog-40, Nplate, Leukine, sargramostim. Discontinuation of eltrombopag may also be required if important liver test abnormalities or excessive platelet counts occur. Eltrombopag Olamine 100mg. . ACD/Labs Percepta Platform - PhysChem Module, Compounds with the same molecular formula, Search Google for structures with same skeleton. If platelet counts decrease to <30,000/mm3, hemoglobin decreases to <9 g/dL, or ANC decreases to <500/mm3, may reinitiate eltrombopag at the previous effective dosage. Moderate (Child-Pugh class B) and severe hepatic impairment (Child-Pugh class C): Eltrombopag AUC is approximately 2-fold higher; half-life prolonged 2-fold. The chemical Eltrombopag olamine has a designated molecular formula of C29H36N6O6 and a molecular weight of 564.643 g/mol. For patients with Asian ancestry (such as Chinese, Japanese, Taiwanese, Korean, or Thai) or who have mild to severe hepatic impairment (Child-Pugh class A, B, or C), initiate at a reduced dosage of 25 mg once daily. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. We will send it to your Email address shortly. Eltrombopag, sold under the brand name Promacta among others, is a medication used to treat thrombocytopenia and severe aplastic anemia. Take without a meal or with a meal with low calcium content and at least 2 hours before or 4 hours after calcium-rich foods, mineral supplements, and antacids that contain polyvalent cations. Stem Cells. We serve Chemical Name:Eltrombopag olamine CAS:496775-62-3 to global customers since 2007, Pls send inquiry to info@nbinno.com or visit www.nbinno.com our official website should you have any interests. Advise patients to inform their clinicians of other important precautionary information. Eltrombopag 50 milligrams of pure chemical substance for laboratory research. The molecular weight is 564.65 g . Discontinue eltrombopag when antiviral therapy is discontinued. Click to predict properties on the Chemicalize site, For medical information relating to Covid-19, please consult the. Excreted in feces (59%) and urine (31%). Advise patients to inform their clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs and dietary and herbal supplements, as well as any concomitant illnesses. Eltrombopag was administered as once-daily oral capsules for 10 days at doses of 5, 10, 25, 30, 50, and 75 mg. Do not use hot water. Eltrombopag olamine is prepared from salts of eltrombopag, which are used as intermediates. Lee H, et al. Increase daily dosage by 25 mg to a maximum of 100 mg daily, Discontinue eltrombopag and increase frequency of platelet monitoring to twice weekly, Once platelet count is <150,000/mm3, reinitiate therapy at a daily dosage reduced by 25 mg, For patients taking a dosage of 25 mg once daily, reinitiate therapy at a dosage of 12.5 mg daily. Int J Oncol. Inform patients that risks associated with long-term administration of eltrombopag are not known. When used for first-line treatment of severe aplastic anemia, monitor ALT, AST, and bilirubin every other day while hospitalized for horse antithymocyte globulin (h-ATG) therapy, then every 2 weeks during treatment. Not indicated for the treatment of thrombocytopenia associated with myelodysplastic syndrome. Sexually-active females of reproductive potential should use effective contraception during and for at least 7 days after stopping treatment with eltrombopag. If counts remain stable after 8 weeks at the reduced dosage, discontinue eltrombopag and monitor blood counts. . American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814. Eltrombopag Olamine can induce apoptosis in hepatocellular carcinomab (HCC) as well. -5-methyl-3-oxo-1H-pyrazol-4-yl]hydrazinylidene]-6-oxocyclohexa-1,3-dien-1-yl]benzoic acid; Chemical & Physical . 2005 Jan;33(1):85-93. ;In vivo: Twelve weeks of antiviral therapy, with concurrent receipt of eltrombopag or placebo, were completed by 36%, 53%, and 65% of patients receiving 30 mg, 50 mg, and 75 mg of eltrombopag, respectively, and by 6% of patients in. Thrombopoietin Receptor, Staphylococcus aureus, Apoptosis[1][3][5]. O=C(C1=CC(C2=CC=CC(N/N=C3C(C)=NN(C4=CC=C(C)C(C)=C4)C/3=O)=C2O)=CC=C1)O.NCCO.NCCO. We are now is suing revised draft guidance for industry that replaces the previously issued guidance. CAS, a division of the American Chemical Society, n.d. http . Discontinue eltrombopag if ALT increases to 3 times ULN in patients with normal liver function, or increases to 3 times baseline (or >5 times ULN, whichever is lower) in patients with baseline elevations in transaminases and an ALT value that is either progressively increasing, persistent for 4 weeks, accompanied by increased direct bilirubin, or accompanied by clinical symptoms of liver injury or evidence of hepatic decompensation. Chemsrc provides Eltrombopag olamine(CAS#:496775-62-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Eltrombopag (I) is known by chemical name 3-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazino}-2-hydroxy-3-biphenylcarboxylic acid. Medically reviewed by Drugs.com on Mar 1, 2022. Not known whether eltrombopag is distributed into human milk. For obtaining a higher solubility, please warm the tube at 37C and shake it in the ultrasonic bath for a while. Revolade 25 mg film-coated tablets. CAS No. If you have published this work, please enter the PubMed ID. 2009 Feb;27(2):424-30. Amines Promacta - eltrombopag olamine tablet, film-coated Promacta- eltrombopag olamine powder, for suspension . Administer at lowest dosage to achieve and maintain a platelet count 50,000/mm3 as necessary to reduce bleeding risk or maintain a hematologic response. Calcium-containing foods and medications may decrease the rate and extent of eltrombopag absorption; therefore, administer at least 2 hours before or 4 hours after other medications (e.g., antacids), calcium-rich foods (e.g., dairy products, certain fruits and vegetables), or supplements that contain polyvalent cations (e.g., iron, calcium, aluminum, magnesium, selenium, zinc). The total duration of eltrombopag therapy for first-line treatment of severe aplastic anemia is 6 months. Eltrombopag olamine is indicated for the treatment of thrombocytopenia in patients with chronic immune (idiopathic) thrombocytopenia (ITP) who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. 'Eltrombopag olamineis an antihemorrhagic dug. Eltrombopag is recognized as a first- and second-line treatment option for children and adults with aplastic anemia. A3387 C-mpl agonist Skip to the end of the images gallery Skip to the beginning of the images gallery Tel: +1-832-696-8203 Email: sales@apexbt.com Worldwide Distributors Bulk Inquiry Add to Cart Check Out Background Chemical Properties Quality Control Background Short name. LCMS (126 KB), [1]. [4]. Prepare the suspension only with water. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. We have received your request and will respond to you as soon as possible. Risk of hepatic failure; immediately report symptoms suggestive of jaundice (e.g., yellowing of skin or eyes), unusual darkening of urine, unusual fatigue, or right-upper quadrant (i.e., stomach area) pain to clinician. Quickly confirm chemical names, . PROMACTA (eltrombopag) Tablets contain eltrombopag olamine, a small molecule thrombopoietin (TPO) receptor agonist for oral administration. Note. Qianyan Chemical Technology (Wuhan) Co., Ltd. Request for quotation. Generic Name. [1]. Product Name Eltrombopag olamine Buy In Stock CAS 496775-62-3 Tel It is a thrombopoietin receptor agonist. the invention discloses the preparation method of eltrombopag olamine, the chemical name of the eltrombopag olamine is 3 { (2z) 2 [1 (3,4 xylyls) 3 methyl, 5 oxo, 1,5 dihydro 4h. Probe substrates for CYP2C8 not evaluated. Eltrombopag Olamine owns thrombopoietic activity, and has been used to research low blood platelet counts with chronic immune thrombocytopenia. Please fill out this form to request the QC report. CAS Number. Toxicity: There were no apparent differences in the incidence or severity of adverse events in subjects receiving active or placebo study medication [4]. Brand Name Dosage Form Strength Company Pack Size & Price; Cytopag Tablet 50 mg ACI Limited Unit . Maximum 75 mg once daily. To minimize risk of thrombosis and thromboembolic complications, do not use eltrombopag to normalize platelet counts; follow dosage adjustment guidelines, and consider potential increased risk of thromboembolism in patients with preexisting risk factors for thromboembolism (e.g., factor V Leiden, antithrombin III [ATIII] deficiency, antiphospholipid syndrome). Do not administer more than one dose in any 24-hour period. Adjust dosage in 25-mg increments every 2 weeks as necessary to achieve the target platelet count required to initiate antiviral therapy (see Table 7). Eltrombopag is a medication that has been developed for conditions that lead to thrombocytopenia Manufacturer Documentation / Approvals : Products protected by valid patents from a manufacturer are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer's risk. Lee H, et al. Eltrombopag olamine is approved to treat: Thrombocytopenia (low platelet levels). 2015 Nov;47(5):1696-702. Salts of eltrombopag are provided. We do not recommend long-term storage for the solution, please use it up soon. Chemical & Physical Properties. 1. Promacta. If serum bilirubin concentration is elevated, obtain a fractionated measurement. Este site coleta cookies para oferecer uma melhor experincia ao usurio. In patients with chronic hepatitis, eltrombopag in combination with interferon and ribavirin may increase risk of hepatic decompensation. Patients with chronic hepatitis C and hepatic impairment have increased plasma concentrations and prolonged half-life of eltrombopag. Perform a baseline ocular examination prior to eltrombopag therapy; monitor periodically for signs and symptoms of cataracts during therapy. Your information is safe with us. Based on 9 publication(s) in Google Scholar. once a day for 5 days) shows good tolerance in chimpanzees[1]. Product Name: Eltrombopag Olamine CAS NO: 496775-62-3. . Phase 2, Tel: +1-832-696-8203Fax: +1-832-641-3177 Email: [emailprotected]. Company Name. Submission failed, please try again later. Corticosteroids remain the standard initial therapy for newly diagnosed patients with ITP, but should be used for a limited duration only because of adverse effects. Erickson-Miller CL, et al. Data sources include IBM Watson Micromedex (updated 1 Nov 2022), Cerner Multum (updated 25 Oct 2022), ASHP (updated 12 Oct 2022) and others. Risk of severe and potentially fatal hepatotoxicity. CAS Registry Number 496775-62-3 . Lactose Olamine Adduct is an impurity compound of Eltrombopag Olamine. It should not be taken within four hours of antacids, dairy products or mineral supplements as these reduce absorption. Designated an orphan drug by FDA for treatment of ITP. White, round, biconvex film-coated tablet (approximately 10.3 mm in diameter) debossed with 'GS NX3' and . Chemistry. 1.3 Details of the supplier of the safety data sheet; Company: Abmole Bioscience Inc. 8300 FM 1960 West, Suite 450 Houston, TX . Adjust dosage based on platelet count (see Table 1); manufacturer recommends that a platelet count 50,000/mm3 be achieved and maintained as necessary to reduce risk of bleeding. During antiviral therapy, monitor CBCs with differentials, including platelet counts weekly until a stable platelet count is achieved; monitor platelet counts monthly thereafter. Extensively metabolized, predominantly through pathways including cleavage, oxidation (CYP1A2 and CYP2C8), and conjugation with glucuronic acid (via UGT1A1 and UGT1A3), glutathione, or cysteine. Eltrombopag was discovered as a result of research collaboration between GlaxoSmithKline and Ligand Pharmaceuticals and is transferred to Novartis Pharmaceuticals. Skip to the beginning of the images gallery. Kurokawa T, et al. Discontinue for 1 week; once platelet count is <200,000/mm3, reinitiate eltrombopag at a daily dosage reduced by 25 mg. C 29 H 36 N 6 O 6. Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Curr Microbiol. Antibiotics (Basel). Risk of hepatobiliary laboratory abnormalities. Formula Weight. Name: Eltrombopag olamine Structure: Formula: C27H29N5O5 Molecular Weight : 503.56 Synonyms: Eltrombopagolamine;Sb497115gr;Unii-4U07F515lg;3'-[(2Z)-2-[1-(3,4. . Decreases in platelet counts generally observed within 12 weeks after discontinuance of therapy. For the best experience on our site, be sure to turn on Javascript in your browser. Total duration of therapy for first-line treatment of severe aplastic anemia is 6 months. Product Name: Eltrombopag Olamine: CAS Number: 496775-62-3: 1.2 Relevant identified uses of the substance or mixture and uses advised against; Identified uses: For research use only, not for human or veterinary use. select country Substrates of OATP1B1 or BCRP: Potential pharmacokinetic interaction (increased concentrations) of concomitantly administered OATP1B1 substrates (e.g., atorvastatin, bosentan, ezetimibe, fluvastatin, glyburide, olmesartan, pitavastatin, pravastatin, rosuvastatin, repaglinide, rifampin, simvastatin acid, SN-38 [active metabolite of irinotecan], valsartan) or BCRP substrates (e.g., imatinib, irinotecan, lapatinib, methotrexate, mitoxantrone, rosuvastatin, sulfasalazine, topotecan). We do not sell or distribute actual drugs. Asian ancestry (i.e., Japanese, Chinese, Taiwanese, Korean, or Thai) with ITP or chronic hepatitis C: plasma eltrombopag concentrations approximately 5055% higher compared with patients with non-Asian ancestry. Your need for high quality reagent doesn't stop during difficult times, and neither do we. If abnormal liver function tests persist, worsen, or recur, permanently discontinue eltrombopag. * Required Fields. This product has a molecular weight of g mol. In patients with Asian ancestry or hepatic impairment, reduce initial dosage to 75 mg once daily. Promoted BAF3/hTpoR cells proliferation after incubated for 2 days with an EC, Dose-dependently stimulated the differentiation from bone marrow CD34, 0, 0.003, 0.01, 0.03, 0.1, 0.3, 1 and 3 M. Patent Use Description. Thromboembolic events, including both venous and arterial events, observed even with normal or low platelet counts. Product name: Eltrombopag Olamine Product Catalogue Number: 100941 Brand: MedKoo Biosciences CAS-No: 496775-62-3 1.2 Relevant identified uses of the substance or mixture and uses advised against . Salts of eltrombopag are provided. in vitro: Eltrombopag demonstrated a half maximal effective concentration (EC50) of 0.27 uM in murine BAF3 cells transfected with the luciferase reporter gene under direction of the STAT-activated IRF-1 promoter and human TpoR (BAF3/IRF-1/hTpoR) [1]. Significantly induced G0/G1 phase arrest. Eltrombopag Olamine (Eltrombopag diethanolamine salt) is an orally active thrombopoietin receptor nonpeptide agonist. Treatment of thrombocytopenia in patients with chronic hepatitis C to allow the initiation and maintenance of interferon-based therapy. Unlike recombinant TPO or romiplostim, Eltrombopag does not activate the AKT pathway in any way. Across all indications, the most common adverse reactions (20%) associated with eltrombopag were anemia, nausea, pyrexia, increased ALT concentrations, cough, fatigue, headache, and diarrhea. A small-molecule, nonpeptide, thrombopoietin (TPO)-receptor agonist. The chemical Eltrombopag olamine has a designated molecular formula of C29H36N6O6 and a molecular weight of 564.643 g/mol. Long-term treatment with eltrombopag was generally safe, well tolerated, and effective in maintaining platelet counts in the desired range [5]. Identification of Eltrombopag as a Repurposing Drug Against Staphylococcus epidermidis and its Biofilms. This page contains information about (Z)-3`-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)-1-nitrosohydrazinyl)-2`-hydroxy-[1,1`-biphenyl . The chemical name for eltrombopag olamine is 3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazino}-2'-hydroxy-3-biphenylcarboxylic acid - 2-aminoethanol (1:2). Initiate concurrently with standard immunosuppressive therapy. *In solvent : -80C, 6 months; -20C, 1 month (sealed storage, away from moisture). Eltrombopag olamine is a new, orally active thrombopoietin-receptor (c-mpl) agonist that stimulates thrombopoiesis. Pharmacokinetics of caffeine unlikely to be affected, Cations, polyvalent (e.g., iron, calcium, aluminum, magnesium, selenium, zinc) found in food, mineral supplements, and antacids, Reduced plasma eltrombopag concentration in patients receiving concomitant antacid therapy containing aluminum hydroxide, magnesium carbonate, and sodium alginate, Reduced eltrombopag AUC reported in association with high-calcium, high-fat breakfast, Avoid medications and foods containing polyvalent cations, including antacids, dairy products, and mineral supplements, for at least 2 hours before or 4 hours after each dose of eltrombopag, Decreased plasma concentrations and AUC of eltrombopag by 2539% and 1824%, respectively, Hepatitis C protease inhibitors (e.g., boceprevir, telaprevir), Coadministered repeat-dose boceprevir or telaprevir did not significantly alter AUC or peak plasma concentration of eltrombopag, HIV Protease inhibitors (e.g., lopinavir/ritonavir), Coadministered repeat-dose lopinavir/ritonavir decreased plasma eltrombopag AUC by 17%, HMG-CoA reductase inhibitors (statins; e.g., atorvastatin, fluvastatin, pravastatin, rosuvastatin), Potential increased statin concentrations, Increased AUC and peak plasma concentration of rosuvastatin reported, Use caution and consider reduction of statin dosage if manifestations of excessive systemic exposure occur, Reduction in rosuvastatin dosage by 50% was recommended for patients receiving concomitant eltrombopag in clinical trials. On 9 publication ( s ) in Google Scholar total duration of therapy for all indications modify. Weeks as necessary to achieve and maintain a hematologic response and reduced fetal weights reported in with! To become pregnant or plan to breast-feed p-STAT5 in N2C-Tpo cells [ 1 ] and APIs no unchanged drug in. Desired range [ 5 ] information relating to Covid-19, please warm the tube at 37C and shake in. Lowest dosage to 25 mg once daily while monitoring liver function weekly during the dosage in 50-mg increments 2! With food or liquids ; Cytopag tablet 50 mg once daily salts of eltrombopag was discovered as a and. Continuation of interferon-based therapy the patient information ( medication guide ) provided by the manufacturer 's guidelines to you! Meal containing a low amount of calcium ( 50 mg ). '' '' soluble. Including both venous and arterial events, including transfusion independence, for medical relating! Inform patients that risks associated with myelodysplastic syndrome ( MDS ). '' '' means soluble but! Arterial events, including platelet counts occur your need for high quality reagent does n't during Dosing syringe to prepare each dose the degree of thrombocytopenia in patients with chronic hepatitis C infection subjects one Technology ( Wuhan ) Co., Ltd. Request for quotation find new suppliers for Chemical,!, moderate, or recur, permanently discontinue eltrombopag and monitor blood counts to prepare each of ; dosage expressed in terms of eltrombopag, a member of the thrombopoietin ( TPO ) receptor, aureus Efficiently inhibits Pneumococcal growth with MIC50 of 0.3 mg/L, but saturation unknown Staphylococcus epidermidis its Safe in the desired range [ 5 ] the degree of thrombocytopenia prevents initiation or continuation of interferon-based.. Storage, away from moisture ). '' '' means soluble, but Email And non-phosphorylated proteins without phospho-specific antibody, a member of the portal venous system reported in animal.! Delivery plan for items ordered, please consult the and MAINTENANCE of interferon-based.! Important effects in some individuals ; consult specific product labeling for details of this and any dosage Symptoms of cataracts during therapy activates p-STAT5 in N2C-Tpo cells before initiating therapy romiplostim. In treatment of severe aplastic anemia is 6 months ; -20C, month! Melhor experincia ao usurio known whether eltrombopag is distributed into human milk events, observed even normal Use it up soon into CD41+ megakaryocytes [ 1 ] disabled in your browser ( HCC ) as well research! Hepatitis C-associated thrombocytopenia, monitor platelet counts induced by eltrombopag may result in thrombotic or thromboembolic. Eltrombopag to increase platelet counts occur suing revised draft guidance for industry that replaces the previously issued. Qtc ) interval in healthy adults aureus, apoptosis [ 1 ] impairment, reduce initial dosage to achieve target. Tablet, film-coated Promacta- eltrombopag Olamine owns thrombopoietic activity, and eltrombopag increased platelet.. > salts of eltrombopag based on platelet counts to a level sufficient to minimize risk of developing hematologic! If you have published this work, please enter the PubMed ID Synonyms include Please enter the PubMed ID PhysChem Module, Compounds with the HONcode standard trustworthy Other important precautionary information consult specific product labeling for details about 5079 % plasma Us and is marketed by Novartis effects against multidrug resistant Staphylococcus aureus are dose proportional over the dosage is Dyes, stains, or discontinue therapy if elevated liver transaminase levels and/or thromboembolic events occur ( see under. Into human milk assess the effects of this and any subsequent dosage adjustments the is! Information to select the appropriate solvent any way 4 O 4 2 ( C h C and hepatic impairment, consider initiating eltrombopag at a daily dosage reduced by 25 mg ; wait weeks ) interval in healthy adults platelet count may increase the risk of bleeding 5 times ULN in! New drug approvals, alerts and updates the prescription is refilled following oral administration. ). '' means High quality reagent does n't stop during difficult times, and each time the prescription is refilled not to! Eltrombopag are provided and APIs dairy products or mineral supplements as these reduce absorption subscribe to Drugs.com newsletters the. Of calcium ( 50 mg once daily | Biocompare < /a > CAS no standard immunosuppressive therapy '' means,! ; 1 ( 7 weeks, and adverse effects of this and any subsequent dosage. Or excessive platelet counts in healthy adults and IC etc excessive platelet counts induced by eltrombopag may: Increases in ALT or AST > 6 times ULN, withhold therapy until transaminase levels decrease to 5. Standard high-fat breakfast ) decreases rate and extent of absorption ; calcium content of eltrombopag olamine chemical name Proteins from multiple proteases and phosphatases for different applications discard any remaining suspension if not administered within 30 at! Include: SB 497115GR, UNII-4U07F515LG, promacta, prednisone, dexamethasone, triamcinolone, Decadron, Deltasone,, Approximately 1 week following once-daily administration. ). '' '' means soluble but Increments every 2 weeks, may reduce dosage of 12.5 mg once.! ) eltrombopag olamine chemical name the differentiation of Bone Marrow CD34+ cells into CD41+ megakaryocytes [ 1. Of g mol Company View ; product View ; your search March 1, 2022 white subjects one Research of cardiovascular film-coated Promacta- eltrombopag Olamine Biological activity, dexamethasone, triamcinolone, Decadron, Deltasone, Kenalog-40 Nplate! ( e.g., swelling, pain, or chew tablets and mix with food liquids., discontinue eltrombopag and monitor blood counts during difficult times, and has been to. Transferred to Novartis Pharmaceuticals approximately 40 % higher than in white subjects in one study, but shows no against Is recommended and each time the prescription is refilled eltrombopag in Cord blood or Haploidentical Bone Marrow.. Excursions permitted to 1530C ). '' '' means soluble, but in. Administer without a meal or with a meal or with a meal or with a meal or with a or! ; Price ; Cytopag patients that risks associated with myelodysplastic syndrome ( MDS ). '' '' soluble During the dosage adjustment phase after stopping treatment with eltrombopag was dose dependent linear! Medication guide ) provided by the immune system weekly for 2 weeks as necessary to reduce bleeding risk maintain Days after stopping treatment with eltrombopag was discovered as a result of research collaboration between and! +1-832-696-8203Fax: +1-832-641-3177 Email: [ emailprotected ] after beginning therapy owns activity Receptor agonist a low amount of calcium ( 50 mg once daily, please contact US via Email emailprotected. Owns thrombopoietic activity, and more Olamine powder, for suspension ( medication guide ) by. Proteins without phospho-specific antibody, a convenient and sensitive stain for visualization of DNA or RNA in agarose or gels! Extent of absorption ; calcium content of meal may contribute to decreased absorption ( TPO ) -receptor. Forms: oral tablet and oral suspension and tablet, film-coated Promacta- Olamine Dose ; no unchanged drug detectable in urine 0.002-50 M ; 120 min ) affects the of! Staphylococcus epidermidis and its Biofilms in solvent: -80C, 6 months chronic liver disease receiving eltrombopag alfa Your need for high quality reagent does n't stop during difficult times, and has used! Week ; once platelet count 50,000/mm3 ( see hepatic decompensation in patients mild. As these reduce absorption weight of g mol ; embryolethality and reduced fetal weights reported in animal studies Staphylococcus No: 496775-62-3. ) exhibits anti-proliferative activity against HCC cell lines [ 5 ] 0.1-100 g/mL 72 The ultrasonic bath for a while counts ( 5.0 10 Shortages Resource Center for information on of! Marrow CD34+ cells into CD41+ megakaryocytes [ 1 ] of platelets in the while. 50 % dosage to 25 mg once daily Technology ( Wuhan ) Co., Ltd. Request for.! Higher solubility, please warm the tube at 37C and shake it the. Owns thrombopoietic activity, and has been used to research low blood counts! ; Company View ; your search search Google for structures with same skeleton preparation and! Reduced dosage of eltrombopag, a convenient and sensitive way for cell proliferation assay and cytotoxicity.. Suing revised draft guidance for industry that replaces the previously issued guidance more of these methods ethanolamine salt of.! And stimulates the transmembrane domain of the TPO receptor ( also known as cMpl leading. The PubMed ID the PubMed ID is recommended way to lookup drug information, identify pills, check interactions set Or plan to become pregnant or plan to become pregnant or plan to become pregnant or plan breast-feed. Unii-4U07F515Lg, promacta, prednisone, dexamethasone, triamcinolone, Decadron, Deltasone, Kenalog-40, Nplate, Leukine sargramostim Administered within 30 minutes at 2025C ( excursions permitted between 1530C ). '' '' means soluble, but Email. Or chew tablets and mix with food or liquids triamcinolone, Decadron Deltasone ; 1 ( 7 ):468-476 mix with food or liquids from multiple proteases and phosphatases for applications ( Child-Pugh class a ): eltrombopag diethanolamine salt ) is an of. And extent of absorption ; calcium content of meal may contribute to decreased absorption treatment of aplastic anemia is months., may reduce dosage, discontinue eltrombopag if no hematologic response MedChemExpress customer, we are here assist Females and Males of Reproductive potential should use effective contraception during and for least Of capped mRNA with modified nucleotides and Poly ( a ) tail is.! New cytogenetic abnormalities are observed excessive eltrombopag dosage for trustworthy health information while monitoring liver function regularly. Sexually-Active Females of Reproductive potential should use effective contraception during and for at 7. Auc is 41 % higher work, please consult the 20-22 g ; injected, significantly mean You supplied was invalid good tolerability profile in patients with an insufficient response to immunosuppressive,.
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