[Ref], Very common (10% or more): Hypotension (10.5%), Uncommon (0.1% to 1%): Palpitations, flushing, hypotension, hypotension leading to syncope or circulatory collapse, Very rare (less than 0.01%): Cardiac arrhythmia (secondary to hypocalcemia), Postmarketing reports: Atrial fibrillation, hypertension, bradycardia, and hypotension[Ref], In the postmenopausal osteoporosis trial, adjudicated serious adverse events of atrial fibrillation in the zoledronic acid treatment group occurred in 1.3% of patients (50 out of 3862) compared to 0.4% (17 out of 3852) in the placebo group. I had three injection of Prolia. pain in bones and muscles, including back, arm, and leg pain high cholesterol levels urinary tract infection (UTI) pancreatitis (swelling of the pancreas) More common side effects in males*. I make sure I get plenty of calcium from my foods and drink lots of water. Just here it is take it. Hypertension. So what was the big success with it? I would love to know when it will stop! They just jumped off the computer screen at us. They all sad it was fine with all my medications for Major Depressive Disorder, anxiety, seizure disorder, macular degeneration. I went to the dermatologist and had to go on steroids and thats what caused my Osteoporosis to begin with. I've been awake for days due to this pain. Australian prescription products guide online. Please push your doctor to get you information Good luck and I wish you well. These can include some mild side effects but also some serious ones. I itch all over my shoulders, legs, face, back etc. Now it is hit to an unbearable level of pain. Funny you mention your teeth, I have had tooth pain and one tooth pulled. How long do the side effects of Prolia last? We called our family doctor and went to his office first thing the next day. [Ref], Very common (10% or more): Alopecia (12%) and dermatitis (11%), Uncommon (0.1% to 1%): Pruritus, hyperhidrosis, rash (including erythematous and macular rash), increased sweating, Frequency not reported: Stevens-Johnson syndrome, epidermal necrolysis, Postmarketing reports: Increased sweating and urticaria[Ref], Very common (10% or more): Nausea (29.1% to 46%), vomiting (14% to 32%), constipation (26.7% to 31%), diarrhea (17.4% to 24%), abdominal pain (14% to 16.3%), dyspepsia (10%), Common (1% to 10%): Stomatitis, sore throat, dysphagia, Uncommon (0.1% to 1%): Gastroesophageal reflux disease, esophagitis, toothache, gastritis, Very common (10% or more): Urinary tract infection (14%)[Ref], Very common (10% or more): Anemia (22.1% to 33%) and neutropenia (12%), Common (1% to 10%): Granulocytopenia, thrombocytopenia and pancytopenia, Grade 3 and 4 laboratory abnormalities have included hypophosphatemia (51.4%, grade 3; 1.4%, grade 4) and hypocalcemia (1.2%, grade 3).[Ref]. Any input is greatly appreciated!! DON'T freaken do the shot almost 2 month's on couch all day. I have had 2 prolia injections and like you I feel like crap. I am meeting with my doctor next week, as I told him I refuse to take any more Prolia injections; however, I have read about the possible complications of discontinuing it, and it really scares me -- but not enough to continue with it.On some mornings, the weakness and pain in my right arm is so severe that it hurts to raise my arm to blow my hair dry or brush my teeth.I really am not one to complain, and I can put up with a lot if I know it will benefit me. The study is based on denosumab (the active ingredients of Prolia) and Prolia (the brand name). Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). Tell me it leaves the body soon. If we combine this information with your protected No one ever explained or mentioned side effects. Novartis Pharmaceuticals (2001): 2. My dr has no answers, loaded me upon vitamins and antidepressants. The last (4th) I cancelled due to severe eczema all over my body, hair loss, deformities of nails, increased body pain. My jaw clicks a bit though it was worse when i started on prolia. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. This site provides the link to submit a complaint. Nothing about side effects or how it might effect all of my other medications! Drug information provided by: IBM Micromedex. I have doing a lot of research on all of this and sometimes they will completely ignore my concerns or twist the questions around and make it sound like something else! All she said to me was you have osteoporosis and the doctor wants you to take fosamax! Just about to give up hope on anything. Question posted by radcoder on 24 July 2012. At times they literally cross out words so the questions are never answered! I had my second Prolia Nov 6, a month ago. Along with its needed effects, zoledronic acid (the active ingredient contained in Reclast) may cause some unwanted effects. It would take me 15 min to get out of my suv. I am 66 years old and am happy with all the other benefits from it. Make your own decisions. . Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Report. The flu like symptoms generally disappears after 24-48 hours and usually occurs only after the first injection. No one seems to know if the side effects will go away in time. It's important to tell your doctor if you have. My bones are so bad I have been on Forteo for two years twice (eight years apart). Red cheeks constipation and flatulence after the prolia. I was diagnosed with osteoporosis about a month ago. The following factors have been associated with an increased risk: Pre-existing renal dysfunction, dehydration, multiple cycles of zoledronic acid (the active ingredient contained in Reclast) or other bisphosphonates, concomitant use of nephrotoxic medicines and use of a shorter infusion time than what is recommended. These are not all the possible side effects of Prolia. My hips felt like they were dislocated, hand pain, bottom of feet burning, bone pain, sinus & ear infections & now hair loss. I had injection #5 on 8-6-18, and the pain after this injection was horrible. . But, after each injections something different. . Last Update: May 30, 2022. I hope it goes away soon. Costochondritis in Clonazepam, how severe and when it was recovered? If you notice any other effects, check with your healthcare professional. If you can call this living. I'm horrified my hip will break and I will fall. Applies to zoledronic acid: intravenous powder for solution, intravenous solution. Some side effects may not be reported. This site complies with the HONcode standard for trustworthy health information: verify here. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. I am 81. The most common side effects of Prolia in men with osteoporosis are back pain, joint pain, and common cold (runny nose or sore throat). I don't recommend this to anyone. I only had one shot,and it was exactly 6 months ago. Is prolia given intravenously? My doctor suggested Prolia and I'm scared to try that. I tke Forteo shots which are daily not every six months like prolia. He/she needs to know of the side effect and your unbearable pain.Good luck to you,Sweet Hippie. All I can say is I SHOULD HAVE DONE MY HOMEWORK. The doctor who prescribed the gave me oral steroids that helped a little but not a lot. 1998-2022 Mayo Foundation for Medical Education and Research (MFMER). Because the drug can stay in your body for up to 6 months, some side effects can still occur months after your last dose of Prolia. The risks with estrogen are very minimal. Prolia side effects are often predictable in terms of their onset, duration and severity. Use or keep moving your arm. I havent had a Prolia injection since 2014! Note: This document contains side effect information about zoledronic acid. I will not be getting anymore! We saw that the drug didn't do great things to bone marrow stem cells. We have no family history of PD. To Doolindalton, How can you even question yourself about getting the Prolia injection when you read how many problems others have had with it? Go to the dr in February. So what! The answer was after about 6 months after your last injection, these effects may GRADUALLY decrease over several weeks OR MONTHS! I also take otezla for psoriatic arthritis. You can use the study as a second opinion to make health care decisions. Medically reviewed by Drugs.com. I just had my second shot and my hands feel like they are going to explode. generic drugs) are not considered. What happened to "First Do No Harm"? Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to zoledronic acid: intravenous powder for injection, intravenous solution. Some reports may have incomplete information. Because the drug can stay in your body for up to 6 months, some side effects can still occur months after your last dose of Prolia. [Ref], Cases of osteonecrosis (primarily of the jaws) have been reported, predominantly in cancer patients taking this drug. If the Prolia injection did cause PD, then perhaps it will go away if your mother doesn't get another injection. For the spine, my T-score increased from -2.8 to -2.3. Available for Android and iOS devices. If so, did you have any side effects from it? There is a problem with This drug has almost completely destroyed my sister's well being both mentally and physically. You may report them to the FDA. But, 85% of the 182 were over 60. 32 Comments. From the very first, the back of my right knee has hurt. Now I am up to 2 more cavities with cautions on 3 more. Available for Android and iOS devices. How long do you treat with Prolia? Fosamax was a pill and I could stop taking that but an injection I wouldn't be able to do anything about. Fosamax can have long term bad effects, e.g. I have no idea why I suddenly remembered this tidbit but here it is!Have a great day:-). It went away (no treatment) after about three or four weeks. My spine feels better since I have started Prolia. How long do the side effects last???? Continue reading for a comprehensive list of adverse effects. And the worst part is her new Dr had no clue about the side effects and never warned her about any of them. Zometa (zoledronic acid)." Kathy I took this damn drug for 5 months, stopped in early March, 2019still having severe leg pain and weakness, spasms, lower back paincannot do things I used to do. Once this is in your system I doubt you can reverse it but Im not sure. Any advice or words of wisdom are welcomed! * Approximation only. Weakness, more pain in my bones, muscle cramps and stomach issues. Since stopping that is fine. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, blistering, crusting, irritation, itching, or reddening of the skin, bloating or swelling of the face, arms, hands, lower legs, or feet, muscle cramps in the hands, arms, feet, legs, or face, numbness and tingling around the mouth, fingertips, hands, or feet, pain in the lower back, bottom, upper leg, or hips, painful blisters on the trunk of the body, clear or bloody discharge from the nipple, itching, pain, redness, swelling, tenderness, or warmth on the skin, lump or swelling in the abdomen or stomach, pains in the stomach, side, or abdomen, possibly radiating to the back, persistent crusting or scaling of the nipple, raised, firm, and bright red patches of the skin on the arm or leg, sore on the skin of the breast that does not heal, pain, swelling, or numbness in the mouth or jaw, excess air or gas in the stomach or bowels, feeling of constant movement of self or surroundings, redness, pain, itching, burning, swelling, or a lump under your skin where the shot was given. I cannot emphasize enough how physically and mentally debilitating taking the drug Prolia was in my sister's case. Good luck to you all. I'm going out on a limb here and thinking no because that would be too hard for most people to have to travel to their doctor every day. I had my second shot in November and the skin problem was much more severe. The pain is still here mostly in my hips and spine. I was told there isn't much research on the drug and it was fast-tracked by being attached to another drug they wanted the FDA to pass. Symptoms usually resolve within three days of onset, but resolution can take up to 7 to 14 days, and some symptoms have persisted for a longer duration. She hasn't had another shot (because I told her tremors were a side effect) but a neurologist seems sure it's PD. The frequency of renal impairment adverse events suspected to be related to this drug was as follows: Multiple myeloma (3.2%), prostate cancer (3.1%), breast cancer (4.3%), lung and other solid tumors (3.2%). Intestinal problems, worsening Fibromyalgia, increasing blood pressure, muscle and nerve pain, back pain, neck pain No MORE! I was advised by my doctor that it will take six months for the Prolia to get out of my system. I have the decision to NOT take anything! I am taking Norco which helps a lot. Since a sudden stop in Prolia usage could have serious side effects, including an increased risk of fracture and a lowering of your bone mineral density. I have severe bone pain in my legs, joint pain in my knees and what feels like sciatica. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. I read a question from another patient who called her doctor because she was having painful side effects from Prolia and she asked the nurse how long the side effects would last. Your doctor seems to be misinformed. How effective is Prolia for osteoporosis? Do you administer those to yourself or have to see a doctor for this. At that time, my spine was -3.7, my femoral neck was -2.6, and my mean femur was -2.5. How long will the side effects of Prolia last? I also feel it in my lower back and sometimes in my knees and ankles during the day. I have maybe 2 good days a week. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. 2018, I had my first Prolia shot after almost five years. I'm going to try yoga. The most common side effects of Prolia include: bladder infection, painful or difficult urination, back pain, muscle pain, and pain in your arms or legs Tell your doctor if you have any side effect that bothers you or that does not go away. The reason I am having so many questions/concerns, and anger about Prolia and Fosamax is because of the answers or denials about how both of these would affect they would have on my Major Depressive Disorder and the meds I take for it as well as how they would affect my Macular Degeneration and the meds I take for it, and finally how they would affect my seizure disorder and the meds it take for it. After approximately 4-5 months the first shot began to wear off and she started feeling somewhat better in January. Has anyone completed the 2 years of injections and if so, was there a signficant change in bone density? My dentition changed. Prolia. . I have been on Prolia for 3-1/2 years. If anything it's gotten a little worse, even on PD medicine and doing PT. Then every joint was horribly painful. Most of these events were not specific to the injection site. loss of appetite. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. http://www.appco.com.au/appguide/default.asp" (2006): 4. She was told that probably after about six months the pain would maybe start to go away gradually, over several weeks to six months it would go away. And sometimes drug side effects last a very long time. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. I am not taking another shot. Dermatologist did a biopsy which said my skin problem was definitely drug induced. He called 911 -- I told everyone about the Prolia but no one at the hospital would listen. Praying for relief.Jill. 2009 to 2012 with no side effects that I knew of. I dont know how I got it. It's really scary to read all the stuff about Prolia. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. This is a question our experts keep getting from time to time. I have had two Prolia shots had problems after first one,my fibromyalgia was worse but it didn't last long. Some dosage forms listed on this page may not apply to the brand name Reclast. Thanks so much for responding! I had a tooth removed. If you start Prolia injections, you should plan on being on the treatment for at least 10 years. Thank you for your response to my concerns. Not that it will do any good. Not. You may be able to better handle this drug as compared to the prolia. Prolia, well that is a different story. I agree with you about staying away from Prolia. I had read it 3 times because I was shocked! inverted nipple. Really bad pain day and night. Up to now I have none. other information we have about you. I got my first Prolia shot in May of this year. FDA Urges Caution Over Long-Term Use of Bone-Density . I am lucky since they caught my breast cancer early (I hope) but this pain is unbelievable. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. I am fit and 46 and this shot made me feel 20 years older overnight. I had Prolia shot 2 weeks ago, in my tummy and week ago I started to have itching and pain on that side ,now I have shingles on that side! Does anyone know how long this lasts? I only had one shot. I just dont understand why doctors have such a hard time returning these phone calls. 3. The bottom line for me is time! Would like to know of side effects after Prolia infusion from other persons. The use of the eHealthMe site and its content is at your own risk. Along with its needed effects, a medicine may cause some unwanted effects. It feels good to vent about this nasty medicine!!! While generic Fosamax costs roughly $100 to $200 per year and brand-name bisphosphonates slightly less than $1,000 per year, Prolia will cost about $1,650 per year plus the cost associated with an office visit. What medications are available to treat osteoporosis? I had to stop the drug. My mom was recommended Prolia after her breast cancer diagnosis. And the resultant depression, fear, and almost completely giving up on life that goes with that. Its now 6:00 pm, and no response! After taking the first Prolia injection she suffered from constant pain which led normally to her suffering constant depression. Score: 4.2/5 (68 votes) . I do not recommend Prolia to anyone. FYI To the youngest ones here Back in the 90s, pharmacist or tech are required to ask Do you have any questions for the pharmacist ?Walgreens,CVS ,etc told their staff if they were caught NOT asking that question, they would be fined thousands of dollars by the government.Ok more regulations. My doctor tried talking me into Prolia after I refused to take Fosamax! I was advised by my doctor that it will take six months for the Prolia to get out of my system. They are not swollen at all but the pain is unbearable. I told her this evening and have stopped further injections to be safe. I don't think I like this stuff, either. Mayo Clinic does not endorse companies or products. They are not swollen at all but the pain is unbearable. Never again. Inability to concentrate due to pain. My gastroenterologist also advised me against having them. Like generics, biosimilars may cost less than brand-name drugs. There are many options to minimize of prevent the side effects of Prolia. I had my first injection of Prolia on March 7 th and have had adverse effects ever since then. Drs did not mention side effects.Another wanted me to take reclast following my reaction to Prolia. Dermatologic Adverse Reactions: In the same clinical trial in women with postmenopausal osteoporosis, epidermal and dermal adverse events such as dermatitis, eczema and rashes occurred at a significantly higher rate with Prolia compared to placebo. I take calcium tablets and make milk shakes with almond milk and take a pain pill. The best advise I can give to everyone, change your eating habits and excercise, especially the weight bearing ones, walk everyday and stay happy WITHOUT PROLIA.Good luck everyone. Data sources include IBM Watson Micromedex (updated 1 Nov 2022), Cerner Multum (updated 25 Oct 2022), ASHP (updated 12 Oct 2022) and others. I stopped 2 years ago after 2 Prolia shots and sustained a vertebrae fracture so there is truth in this. First of all, I really think the doctor should have called me and discuss everything. The longer you take Prolia Injection the bigger the improvement in fracture risk when compared to placebo. Just like bumps into items. That's because virtually every drug has the potential to cause adverse reactions for some patients. Upper respiratory infection. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. What's the difference between Prolia and Reclast? The people with bad reactions are probably just a few percentage points, so the doctors tell you that none of their other patients have had any problems. Prolia and you will see more problems. I realize I need take extra calcium. I'm having pain too. I dont know who to talk to! I have witnessed significant changes in my sister since she was introduced to Prolia last September and I can attest to the significant physical pain and mental anguish she has suffered from taking this medication and the transformation to a living hell. information submitted for this request. It is often used in osteoporosis. Excessive pain behind right knee, severe abdominal pain, diarrhea. No one seems to know how long this will last. Common Prolia side effects: Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 625 reports. It sounds like it could be an allergic reaction of some sort. We study millions of patients and 5,000 more each day. Took me at least 20 min to get in & out of my suv. I don't remember having this bad of a reaction with the first shot. I was on Prolia from aprox. The most common side effects of Prolia in women being treated for osteoporosis after menopause are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection. When the side effects will end, no one knows. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. For me, I drink more milk and have been eating very good healthy bone building veggies and products. I hope all who read this make a very informed choice whether to take it or not. After a week or so, the pain subsided and I thought it was over. Markowitz GS, Fine PL, Stack JI, et al. I also saw my physical therapist. Atypical femoral fractures occur when Prolia use is greater than 5 years. O 0, 5. Community Discussion: "I got my shot in my left arm and I have had stronger issues with my left side. I get nervous when I see all the the side effects involving much of the body .This multi-system list of side effects involving so many organs, connective tissue, muscles,bones, etc are ones I dont take unless the pros outweigh the cons.The Pharmacist is a great one to ask medication questions. The next day I got a list of all of the side effects!!!
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