BaseScope and miRNAscope are rapidly becoming material contributors to our spatial biology franchise. Over the long-term, the interest rate environment is a substantial net positive for net investment income overall. If you go back to Q2, we're around 28.2% overall for the cabozantinib franchise. For the third quarter 2022, the company reported total revenues of approximately $412 million, which included cabozantinib franchise net product revenues of $366.5 million. ADU-1805 binds to all alleles, meaning that patients can be treated without being genotypes in contrast to the BI antibody, which binds tightly to only the V1 allele, meaning that patients must be genotyped to assess which alleles they can carry prior to treatment. The teams been outstanding. Yeah. Are you in charge of the data release or is that a Roche decision? Okay, thats great, and then last one, if I could squeeze in, on Wilson Wolf, I didnt hear an update. Our net leverage ratio remains well below one times TTM EBITDA. At this time, all participants have been placed in listen-only mode. For CONTACT-02, our phase 3 study in combination with atezolizumab in metastatic castrate-resistant prostate cancer, we are projecting that enrollment will be completed in the first half of next year. In the first quarter, we continued to build on our leading position in the small to midsized Specialty segment. OK. Yeah, I also have a quick question about maybe how you're thinking in terms of XL092, the ability to salvage cabo pretreated patients in RCC. Namocell, our new acquisition, weve almost doubled their headcount in the six months weve owned them, but in other areas that were maybe looking softer to antibodies [indiscernible] we talked about this quarter, were looking at mission critical needs and replacements and looking at as we expand. So I remember from the triple meeting, the data was mostly generated from either the three consecutive day and five consecutive day schedule. [Operator Instructions] Please note this event is being recorded. As you may know, supplemental payments refer to additional charges identified after a claim has been settled and after repair work has been completed. I would say overall, I know our cell and gene therapy and our gene proteins, we didnt have a 50%-plus quarter like wed been doing. Our team remains highly focused and motivated to compete every day to bring the benefit of CABOMETYX to all eligible patients as we continue to build the franchise and serve patients. We look forward to evaluating this novel combination across multiple solid tumors. Im more concerned about losing great people and getting behind all this attrition. Had those two regions not underperformed relative to the U.S. and to their historical performance, relative performance, we probably would be talking about double-digit growth in Q1 as opposed to something below that, even with the tough comp. Developing mechanisms for preferentially delivering cytotoxic compounds to tumors has been a long-standing goal with antibody-drug conjugates representing the most validated and successful mechanism for doing this. Bob, thank goodness you got in. Okay, great. Yes, so STELLAR-002 still in early days. Furthermore, within the quarter, we saw particular strength in both demand and new patient starts in September. So dose escalation with XB002 continues at this point. We are watching this like a hawk. Joining me on today's call are Mike Morrissey, our president and CEO; Chris Senner, our chief financial officer; P.J. And we will continue to demonstrate our resilience and take advantage of the opportunities ahead, creating value over the long-term. Our expense ratio for the first quarter of 2022 was 31.1% compared with 31.6% in the first quarter of 2021 and in line with our 2022 full year target of 31.1%. In preclinical models, Cybrexa have shown that following administration of CBX-12, both intact CBX-12 and free exatecan, accumulates in tumors, whereas exatecan levels in bone marrow cells remain very low. I would say Akoya is still more in the future. We dont see a lot of issues against price and we dont see any issues, really, from September on. Foreign exchange translation had an unfavorable impact of 3% and acquisitions had a favorable impact of 1% to revenue growth. We sustained healthy rate increases in the past and the renewal rates we are seeking are reasonable. I think the key question that were getting here is how should we think about protein sciences in the second quarter here, how much of this was really sort of pull forward of demand versus actual weakening of demand, as you talked about Europe and China, and--because I cant recall a time when you had 3% organic growth in this segment, so maybe just walk us through what you see now and how should we think about the next quarter and for the full year. We cant work on them all and launch them all ourselves, so, but we have strong interest and a good channel partner that has strength in their area, like Thermo does, with ExoTru--you know, were going to do that. Now moving on to Personal Lines. At the same time, we continue to set our reserves with the expectation that social inflation has not abated, but rather was temporarily deferred during the pandemic. Got it. Mike Morrissey -- President and Chief Executive Officer. Just on STELLAR-303 in CRC, when can we see data around that? In addition, we are implementing an array of non-rate programs, including using aerial imagery to help better identify property hazards and perils and leveraging our advanced technology tools to estimate house replacement values more precisely. And maybe I'll let Bryan Salvatore, kind of elaborate on that real quickly. Though we recognize it takes time for rate increases to have the desired effect, we believe we are in a trajectory to bring our profitability in Personal Lines back to target, top quartile return levels in 2023 from the slightly elevated loss ratio in 2022. Thanks. Thanks, Andy, for your questions. ENVISTA EXCHANGE OFFER ANNUAL REPORT & PROXY . In response, we remain thoughtful in our underwriting philosophy and pricing actions and certainly in our prudent reserving processes. Roche | Investors The reagents are important, theyre critical, but youre going to have to show more than just price and things to work your way in, and whereas were in the pole position in regen but were not in cell and gene therapy, so were still fighting some big competitors out there with Celgene, [indiscernible] and others, but were holding our own and growing nicely and its coming, so. And when do you expect the dose escalation to complete? Please go ahead. Thank you. Thinking about rate in Core Commercial, I was wondering if we could just get kind of any more color on the rate being achieved across different lines of business and I guess just the how you see the gap between the rate being achieved and loss cost trends? Please disable your ad-blocker and refresh. Operating margin for the protein sciences segment was 43.0%, a decrease of 270 basis points year-over-year with productivity gains more than offset by the impact of foreign exchange, price versus inflation dynamics, the fiscal year 22 carryover of strategic investments to support future growth, and the Namocell acquisition. We have seen a gradual increase in supplemental payments through most of 2021 and an acceleration of this trend into the beginning of 2022, causing us to take $13.6 million of unfavorable development, stemming mostly from fourth quarter 2021 claims. Sjgren's syndrome is an autoimmune disease that is often undiagnosed and misdiagnosed with an estimated 4 million Americans currently living with the condition, but 2.5 million undiagnosed. We anticipate that partnership results in the second quarter might be influenced by declining public equity market multiples, as well as interest rate and spread volatility. So this is the triplet combination of nivolumab and ipilimumab with cabozantinib versus a control arm of nivolumab and ipilimumab, which has become a standard-of-care on the basis of demonstrating an overall survival benefit relative to sunitinib in intermediate and poor-risk patients. So I am just kind of curious what we should expect from that line? And then there's a certain amount of clinical work that needs to be completed up to the point at which we can exercise. And finally, turning to our financial guidance for the full year 2022. Yeah. These data were presented by Dr. Toni Choueiri in a presidential symposium at ESMO. Turning to a discussion of our underwriting results by segment, starting with Core Commercial. Press Release Presentation Non . Quarterly Earnings. OK. We expect to see a sizable lift from fixed maturity net investment income in 2022 and an even more meaningful increase in 2023 and beyond. We are totally on our plan for five years and we had been ahead of schedule, and our models are mid single digit in our core anyway, so dont forget that. But the investments--you know, as Chuck mentioned earlier, we caught up in a big way in the second half of fiscal year 22, particularly in Q4 with our growth investments, and so its much more surgical in terms of the investments going forward as opposed to hire everyone you can kind of mentality, as it was the past couple years. As we talked about the year, previously, I said, we think we'll come in the range -- or come in around 29%. We are adding people and driving the pipeline and just getting out there, doing more with Wilson Wolfe and our scale ready team to try and get our stuff pulled in, focusing as much on regenerative medicine as we are in cell and gene therapy, because we are the leader in regen medicine for reagents whereas we arent in cell and gene therapy, and we have a lot of buy-in there. With regards to looking forward, I think Europe is still the biggest question mark. Today's discussion will also reference certain non-GAAP financial measures such as operating income and accident year loss and combined ratios, excluding catastrophes among others. Thank you, Chuck, and thank you all for joining us today. Thanks so much. Demand growth is being driven primarily by the longer duration of therapy for patients on CABOMETYX in combination with nivolumab in first-line RCC. How you think about that increase in exposure and what might act as rate and what might act as kind of increased exposure in the true sense? Great. Our funnel is massive. From a historical perspective, insurance has generally performed well in inflationary environments. So, real pleased with the performance of the team. While there is a level of randomness to property large losses, we are constantly working on our mix and continued to push for needed rate increases in property, which the market certainly supports. In addition to the expanding Maurice capabilities and applications, the platform is also gaining recognition for its environmentally friendly attributes. Was it just some push-out? Like I said, if these bounce back like we think - you know, they come on and they come off and they come back on, [indiscernible] more or less, that will help as well, so. Uptake in the first-line RCC setting is broad across clinical risk groups and practice settings, and prescriber experience to date continues to be very positive. Yeah, Vicki, that was a question about Cybrexa. This represents an expansion of our approach to addressing the myeloid macrophage component of the tumor microenvironment. Turning to Personal Lines, the increase in our Personal Lines combined ratio primarily reflected the impact of increased severity on auto and homeowners claims. So, all of that is really adding to our total growth. Hey. Specifically, the grants donations and sponsorship (GSD) data collection process is detailed here. Good morning. Good morning, and thank you for joining us for our quarterly conference call. And maybe perhaps last question for P.J. We do live in a little different world - we dont have direct competitors, its kind of pieces here and there, and we have a large segment in biotech as well and there is definitely some on the midrange biotech, theres definitely been softness, especially in Europe on signatures and conservatism overall. Our agreement with Sairopa provides us with another potential way of addressing this potentially impactful mechanism of action. Its just taking longer to get the capital signatures. October is also looking okay so far, but there is definitely cautiousness. P.J. In summary, we continue to execute our growth strategy and remain on track to deliver our long term financial targets. And if that sort of correlates with the tumor type that Zyprexa is pursuing right, that delta in terms of pH from healthy to tumor cells? Please go ahead. Roche Holding AG (RHHBY) Earnings Transcripts | Seeking Alpha Hey guys, thank you for taking the questions. The most frequent treatment-related adverse events were GI-related, cytopenias and LFT elevations. We saw continued growth of the cabozantinib franchise in the U.S. while expanding our diverse portfolio of clinical and discovery programs with new collaborations to build the Exelixis product portfolio of the future. Good morning and thank you for joining us. So the general phenomena, I think has been pretty well validated as Peter mentioned from the point of view of the lactate that's involved. The ADC approach relies upon having an antibody to a cell surface protein that is exclusively or preferentially expressed on tumor cells and then covalently conjugating a cytotoxic payload to that antibody. Here, we experienced an exceptionally slower seasonal summer dip in our consumable run rate business. I got a maybe just a couple; P.J. Financial Hanover Insurance Group, Inc.'s (THG) CEO John Roche on Q1 2022 Results - Earnings Call Transcript May 08, 2022 3:18 PM ET The Hanover Insurance Group, Inc. (THG) SA. We are vigilantly watching the signs of returning litigation activity, such as the number of litigated claims and court reopenings. During the course of this presentation, we will be making forward-looking statements regarding future events and the future performance of the company. In the first quarter, we also sustained our auto frequency benefit at a similar level to the fourth quarter of 2021, and we believe this benefit should continue to soften the impact of increased property severity within personal lines, albeit at a potentially lower level as we go through the year. This is P.J. We'll now begin the question-and-answer session. Please go ahead. Media; Investors; Careers; About Roche. Innovation remains a key factor in the growth of our biologics business; for example, we recently unveiled data demonstrating icIEF fractionation on the soon to be launched Maurice Flex instrument. Maurice Flex is scheduled for release in early 2023. From an inventory perspective, this quarter, we came in around 2.3 weeks on hand. Roche has published its Third Quarter Sales results for 2022 prior to the opening of the Swiss Stock Exchange on Tuesday, 18th October 2022. As we have discussed previously, first-line RCC market is very competitive, and we're pleased with the performance of CABOMETYX in combination with nivolumab in this setting. We continue to actively evaluate the most effective and advantageous capital uses in the current environment, including substantial organic growth, as well as capital management opportunities. Furthermore, CABOMETYX total prescriptions, or TRx, have now grown for eight consecutive quarters. If you have an ad-blocker enabled you may be blocked from proceeding. As we've discussed on previous calls, we've been actively engaged in a process of assessing late preclinical and early clinical assets with the aim of identifying multiple opportunities to invest in. But increasingly, we are gaining momentum on kind of lines that travel, if you will, with the rest of the package. ET. And if my 3.5 decades of experience in the P&C industry has taught me anything, it's that in times like these, it's more critical than ever to have an experienced, market-focused, agile and collaborative team to address and overcome challenges, and seek the right opportunities. and/or cause actual results to differ materially from those anticipated. Roche's First Quarter Sales 2022 Clear filter Agenda Overview Pharmaceuticals Division Diagnostics Division Financial Results Questions and answers Severin Schwan, CEO Roche Group Bill Anderson, CEO Roche Pharmaceuticals Thomas Schinecker, CEO Roche Diagnostics Alan Hippe, Chief Financial and IT Officer Hi, guys. For us, when you look at the smaller purchase, what we call a run rate business which is lower dollar value, which is probably 80% of the purchases coming through, the growth in Q2 and continuing here in October continues to be mid-teens growth, particularly here in the U.S. Back to Chucks earlier point, its really the larger bulk purchases that had tougher comps and were more, call it soft this quarter and probably faced more competition with some of the supply chain breaks that were occurring in the larger dollar instrument purchases in terms of competing for dollars. Or where you stand in that process? With that, please see our press release issued an hour ago for our third quarter financial results and an extensive list of key corporate milestones achieved in the quarter. Looking beyond the six current U.S. indications for cabozantinib, we continue to plan for life cycle expansion opportunities as additional phase 3 studies read out in the near future. 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