} December 2018. topOffsetForMinScroll * topOffsetMultiplierLandScape; var target = $(containerID); $(".owl-carousel").owlCarousel({ }, 1000); .text-material-flex { display: flex; margin-bottom: 1rem; padding-left: 15px; } The below materials were developed to help you to self-inject Nplate. Healthcare professionals and patients should be aware, however, that serious risks still exist with Nplate and Promacta. .patient-resources{ background:#eaf6ff; padding:40px 0;} Romy 250mg (Romiplostim) Injection, Intas Pharmaceuticals Ltd, Vial Additional Information for Patients .nplate-btn { background: #d34d2f; border-color: #d34d2f; color: #fff;} MedlinePlus. $(".repatha-link").css("z-index", "1"); The clinical trials upon which the approvals were based were small in enrollment and of relatively short duration. h1.teaser-stage_title { text-align: left; text-transform: none; } a.btn.btn-primary.nplate-btn.video-btn { width: 189px; border-radius: 44px; padding-right: 3rem; position: relative; margin: 29px 0px 0px 92px; text-transform: none;} If you have question, please e-mail Allevaire Indian Team or call Allevaire India on +91-9818274099 (Mr. Kamal Kaushal)/ (Mr. Sanjeev) for further details. It may take up to 4 weeks of before romiplostim is completely effective in preventing bleeding episodes. event.preventDefault(); /* fix blank or flashing items on carousel */ Common romiplostim side effects include (2, 3, 6): Romiplostim side effects that are less common include (2, 3, 6): View the romiplostim side effects section for more detailed information about possible romiplostim side effects. . The romiplostim half-life ranges from 1 to 34 days, with the median half-life being 3.5 days. Romiplostim 250 MCG Injection is used to prevent bleeding episodes in people with chronic immune thrombocytopenic purpura (ITP), a bleeding condition caused by a lack of platelets in the blood. var currentPopUp = $("#" + $(this).attr("data-popupid")); A 2018 study found that a 24-week treatment regimen with romiplostim cost $44,321 for the drug itself and $53,318 when including costs related to visits, tests, and bleeding-related events. var head = document.head; National Cancer Institute. topOffsetForMinScroll += $(".header").height(); .teaser-stage { height: 33%; } Nplate (romiplostim) Information | FDA Romiplostim 500 MCG Injection is used to prevent bleeding episodes in people with chronic immune thrombocytopenic purpura (ITP), a bleeding condition caused by a lack of platelets in the blood. var currentVideo = $(this).find("video")[0]; Romiplostim injection is used to increase the number of platelets (cells that help the blood to clot) in order to decrease the risk of bleeding in people who have chronic idiopathic thrombocytopenic purpura (chronic ITP; an ongoing condition that may cause easy bruising or bleeding due to an abnormally low number of platelets in the blood). $(".close-btn").click(function () { .has-js .external-link-helper_button { width: 55%; margin: 6px 5px;} h4.accordion-heading { margin-bottom: 0.5rem;} Call your doctor right away if you are unable to keep an appointment to receive a dose of romiplostim injection. With the launch of Romy, which is priced at Rs. }); You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. This site is designed to provide patients who have been prescribed Nplate (romiplostim) with information about their treatment and other useful materials. //check if the session storage of isHcp exists or not .accordion_content { font-size: .9rem!important;} controlBar.find(".vjs-time-divider").css("display", "block"); header.addClass("header--sticky"); Background. Amgen is not responsible for the content of this third-party website you are entering now and is not adopting such content into this website. Switching From Romiplostim to Eltrombopag or Vice Versa for Immune Thrombocytopenia: Efficacy and Safety in 46 Patients. #pop_btn { color: #e5004b; border: 2px solid #e5004b; border-radius: 0.3rem; text-align: center; width: 9rem; margin: 0.5rem auto 1.5rem; font-size: 1.35rem; text-decoration: none; height: auto; line-height: 1.3rem; padding: 0.4rem 0 0.45rem; } .accordion_labels::before { font-size: 1rem;} Nplate (romiplostim) was approved on August 22, 2008 and Promacta (eltrombopag) on November 20, 2008 for the treatment of thrombocytopenia in patients with chronic immune (idiopathic) thrombocytopenia (ITP) who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. .teaser-stage {background-color: #FEF1DE; overflow: visible; } .layout-row.layout-row--honestybox .layout-column--honestybox:last-child a.btn.btn-primary { background: #d34d2f; border-color: #d34d2f; } }, 2000); Healthcare professionals should should continue to refer to the drug prescribing information for the latest recommendations on prescribing Nplate and Promacta. .footer-top-container { background-color: #cce3f5; } (8), Romiplostim is available as a powder that is mixed with liquid and administered as a subcutaneous (under the skin) injection, while eltrombopag comes as a tablet and as a powder that is mixed with cold water and taken by mouth. } Do not administer more than one dose from a vial. July 2018. .accordion_content { margin-bottom: 2rem;} Healthcare professionals no longer need to: Enroll in the Nplate NEXUS (Network of Experts Understanding and Supporting Nplate and Patients) Program to prescribe Nplate. }, .patient-resources::before { .video-slider-bg .video-slider-heading .p { color: #fff; } Patients can contact Amgen directly to learn more about whether they are eligible to receive financial assistance. .cookie-bar_text { margin-bottom: 0.5rem; } Romiplostim - Australian Prescriber - NPS MedicineWise 17 PATIENT COUNSELING INFORMATION Advise the patient to read the FDA-approved patient labeling (Medication Guide). items: 1, videojs(videoJsId).ready(function () { Romiplostim | Drugs | BNF | NICE 2,995 for a dose of 250 mcg, the monthly cost of treatment for most patients will be less than Rs.12,000, a huge relief to the chronic ITP patients across the . .banner-btn a.btn.btn-primary { font-size: 0.9rem; } }); .layout-row.layout-row--honestybox .layout-column--honestybox:first-child a.btn.btn-primary { background: #ec951a; border-color: #ec951a; } .slider_pager-item--active, .slider_pager-item:focus, .slider_pager-item:hover { background-color: #0071ce; } nav: true, //for ipad Generally, dissolution of Nplate takes less than 2 minutes. IndiaMART. .honestybox .btn { font-size: 1rem; } Get Best Price. padding-top: 4rem; function stopPlayers() { var elementID = $(this).attr("href").split("#")[1]; .footer-top-container { background-color: #cce3f5; padding: 30px;} Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features. ); Patients no longer need to be enrolled in the Nplate NEXUS (Network of Experts Understanding and Supporting Nplate and Patients) Program or the Promacta. [aria-selected=true] .accordion_labels::before { color: #005480;} Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet. @media (max-width:768px) { .layout-column--teaser-video-row { width: 50%; padding: 0 10px; } .header_nav { right: 0; } .layout-column--teaser-video-row { width: 24.5%; } .footer_logo { width: 150px; } Romiplostim comes as a powder that is mixed with liquid prior to injection and is given once a week. .video-text:hover { color: #000000; } Click the links below to read, download and print these useful support materials. Romiplostim is for use in adults and children who are at least 1 year old. Khellaf M, et al. margin: 10, .honestybox { background: #fff; padding: 0; border-radius: 10px; } .owl-item figure.slider_figure { margin: 0; position: relative; } Romiplostim is given as a subcutaneous injection once weekly. .text-material-flex .material-section { width: 40%; } Eltrombopag must be taken several hours before or after consuming calcium-rich foods such as leafy greens, soy, and dairy products. .material-type {min-height: 6.5rem;} .text-material-flex .material-section { width: 57%; } } var currentPathName = location.pathname; .h1, h1, .h2, h2, .h3, h3, .h4, h4, .h5, h5 { text-align:center; } if (elementID) { romiplostim is a peptibody comprising four tpo-r binding domains (identified by screening mutagenesis peptide libraries 57) with high affinity for the tpo-r (mpl) and one carrier fc domain 4, 5, 58, 59 and has no sequence homology with endogenous tpo ( figure 3 ). .video-js { padding: 0; } $(".teaser_anchor") Romiplostim injection is used to increase the number of platelets (cells that help the blood to clot) in order to decrease the risk of bleeding in adults who have immune thrombocytopenia (ITP; idiopathic thrombocytopenic purpura; an ongoing condition that may cause easy bruising or bleeding due to an abnormally low number of platelets in the blood). DailyMed. You will need frequent blood tests. Applies To: Commercial and Medicaid Expansion Description Romiplostim (Nplate) is a thrombopoietin receptor agonist that increases platelet production through binding and activation of the thromobpoietin (TPO) receptor, similar in mechanism to endogonous TPO. .block700.honesty-bottom .p { font-size: 0.9rem; } .banner.amgevita.nplate-teaser { Ways to Save on Romiplostim Here are some ways that may lower the cost of your Nplate prescription. .teaser-stage { margin-top: 100px!important;} Patients were administered Romiplostim by SC injection once weekly for up to 3 years. Full article: Romiplostim (Nplate) as an effective radiation .teaser--video h4 { padding: 0 0.5rem; min-height: 6rem; margin-bottom: 0; } If your platelet level is too high, your doctor may decrease your dose or may not give you the medication at all. Intas Becomes First To Launch Romiplostim In India .download-flex { justify-content: center; } }); .sticky { position: "fixed"; top: "0px"; width: "100%"; z-index: 11 } .h2, h2 { color: #005480; font-size: 2rem; margin-bottom: 2rem; } a.btn.btn-primary.nplate-btn.video-btn.material { margin: 0;} /****references****/ .click(function (event) { /*******Cookie Message*******/ .layout-column--honestybox { width: 100%; } .teaser--video .teaser_figure img.teaser_image { border-radius: 15px 15px 0 0; } if ($(".repatha-link").length > 0) { @param{name{string}} .block700 { max-width: 700px; width: 100%; text-align: center; margin: 0 auto; } .pil-teaser.patient-teaser { padding: 3rem;} } .text-material-flex { display: flex; margin-bottom: 1rem; padding: 40px; padding-top: 80px;} .pil-teaser.patient-teaser { background-color: #08486a; position: relative; max-width: 1200px; margin: auto; padding: 5rem 6rem 4rem;} .banner-img { width: 100%; margin: 1rem auto; } }); .layout-row.layout-row--honestybox { padding: 2rem; } ROMIPLOSTIM, powder for injection, 100 micrograms, 250 micrograms - PBS img.img-video-pop-up{ cursor: pointer;} if (!isHcp) { After your treatment has continued for some time and your doctor has found the dose that works for you, your platelet level will be checked once every month. position: initial; - The new expiration date must be . 1000: { (7, 8), Amgen, the manufacturer of Nplate (romiplostim brand name), offers copay and reimbursement resources for eligible patients who may need help paying for treatment with romiplostim. .cookie-bar { background: #f4f7f8; } if (windowWidth < 800) { .footer_logo { width: 150px; } } .pil-teaser { padding: 3rem 8rem; } scrollTop: $(target).offset().top - topOffsetForMinScroll, .block700.honesty-bottom { margin-bottom: 8rem; } For the full list of excipients, see section 6.1. .video-slider-heading { max-width: 1024px; margin: 0 auto; padding: 3rem 1rem 1rem; } If you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving romiplostim injection. How long does romiplostim stay in the system? }, Consult a doctor for medical advice about side effects. .has-js .external-link-helper_dialog p.dialog-type-dependent img { width: 25%; display: inline-block; margin-bottom: 0; } Romiplostim is injected under the skin, usually once per week. } Romiplostim is produced by recombinant DNA technology in Escherichia coli (E coli). .has-js .slider { margin-bottom: 1rem; } .h1, h1, .h2, h2, .h3, h3, .h4, h4, .h5, h5 { font-family: MyriadProRg, Helvetica, sans-serif; } var targetNum = target[target.length - 1]; Romiplostim Injection : Overview, Uses, Side Effects, Precautions 3 In the U.S. and European Union, Nplate is approved for the treatment of chronic ITP in adults and in children age one year and older with ITP for at least six . /*****footer****/ (1, 2, 3), Romiplostim works by stimulating the bone marrow to produce a higher number of blood platelets. .patient-teaser.btn.btn-primary { padding: 1rem 0rem;} .material-type.nplate-type3 { min-height: 4rem;} .material-type.nplate-type2 { min-height: 13rem;} prevItem.unbind("click").click(function () { $(this).parent().addClass("vjs-has-started"); A healthcare provider will give you this injection. Your doctor will probably start you on a low dose of romiplostim injection and adjust your dose, not more than once every week.Romy Injection helps in controlling bleeding by speeding up blood clotting. }); February 2020. }. Romiplostim (Subcutaneous Route). Register fr klinische Studien. Romiplostim is a platelet-stimulating medication that is used to treat low blood platelet counts and prevent bleeding in patients with a certain type of blood disorder. nextDot.trigger("click"); These pre-market clinical trials identified several safety concerns for both drugs, including evidence of bone marrow reticulin formation and fibrosis, worsening thrombocytopenia on discontinuation of the drugs, thromboembolic events, and concerns that the marrow stimulatory effects of the drugs could increase the risk of hematological malignancies or progression of malignancy. .has-js .external-link-helper_dialog { padding: 1rem 2rem; } .click(function () { }, 1000); The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. $(this).removeClass("vjs-has-started"); If the victim has collapsed, had a seizure, has trouble breathing, or cant be awakened, immediately call emergency services at 911. .unbind("click") May 7, 2020. .owl-prev::before { content: ''; pointer-events: none; display: block; background-image: url(/static/AMGONE_UMB/img/sprite.svg); background-repeat: no-repeat; position: absolute; top: 50%; left: 50%; -webkit-transform: translate(-50%, -50%); transform: translate(-50%, -50%); width: 18px; height: 16px; background-position: 91.89189% 22.22222%; } }*/, .patient-teaser.btn.btn-primary { background: #08486a; border-radius: 44px; border-color: #fff; text-transform: none;} Romiplostim injection is used to increase the number of platelets enough to lower the risk of bleeding, but it is not used to increase the number of platelets to a normal level. $("video-js").each(function () { Romiplostim Injection drug information | HelloPharmacist .footer_logo { width: 35%; margin-bottom: 1rem; } .material-img img { margin-bottom: 0; } Based in part on this information, FDA has determined that it is appropriate to modify the REMS for both drugs to remove the requirements for restricted distribution and additional adverse event data collection, because these elements of the REMS are no longer needed to ensure that the benefits of the drugs outweigh their risks. Romiplostim injection may cause other side effects. Cancer Network. NDC 55513-221-01 Nplate Romiplostim Injection, Powder, Lyophilized, For .home-img .home-img-flex .right-txt { width: 100%; } /**********Honesty Box*********/ Nplate (Romiplostim) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. romiplostim - Health Information Library | PeaceHealth $(".owl-carousel .item, .img-video-pop-up").click(function () { Introduction. Platelets are a type of blood cell needed to form blood clots and prevent bleeding. Your doctor will monitor you carefully for 2 weeks after your treatment ends. Nplate Platelet Booster | Nplate (romiplostim) $(function () { Based on cohort assignment at time of study enrollment, patients were evaluated for bone marrow reticulin and collagen at year 1 (cohort 1), year 2 (cohort 2), or year 3 (cohort 3) in comparison to the baseline bone marrow at start of the trial. It works by causing the cells in the bone marrow to produce more platelets. .teaser-stage { height: 28rem; } Romiplostim Injection - Romy Injection Latest Price, Manufacturers try { However, the underlying medical conditions in patients with chronic immune (idiopathic) thrombocytopenia (ITP) made the safety data collected by the REMS programs difficult to interpret. .material-type { min-height: 5.5rem;} romiplostim (Nplate) | BCBSND h3.honestybox_heading { margin: 0; } Be sure to mention any of the following: anticoagulants (blood thinners) such as warfarin (Coumadin); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); cilostazol (Pletal); clopidogrel (Plavix); dipyridamole (Aggrenox); heparin; and ticlopidine (Ticlid). parseInt($(".header").css("padding-top").split("px")[0]); 0: { topOffsetForMinScroll * topOffsetMultiplierDesktop; var nextItem = currentParent.find(".owl-next"); items: 4, $(".teaser-stage").css("margin-top", acutalHeaderHeight + "px"); var isHcp = sessionStorage.getItem("isHcp"); .banner-btn a.btn.btn-primary { border-radius: 44px; text-transform: none; font-size: 1rem; margin: 0.5rem 0.5rem 0.5rem 0; padding: 0.5rem 2rem; min-height: auto; line-height: 1; } } The cookie is used to store the user consent for the cookies in the category "Analytics". } // if ($(this).hasClass("vjs-playing")) Find here Romiplostim Injection, Romy Injection suppliers, manufacturers, wholesalers, traders with Romiplostim Injection prices for buying. $(this).addClass("vjs-has-started"); .video-slider-bg1 .owl-carousel .item { box-shadow: none;} Based on cohort assignment at time of study enrollment, patients were evaluated for bone marrow reticulin and collagen at year 1 (cohort 1), year 2 (cohort 2), or year 3 (cohort 3) in comparison to the baseline bone marrow at start of the trial. .owl-next::before { content: ''; pointer-events: none; display: block; background-image: url(/static/AMGONE_UMB/img/sprite.svg); background-repeat: no-repeat; position: absolute; top: 50%; left: 50%; -webkit-transform: translate(-50%, -50%); transform: translate(-50%, -50%); width: 18px; height: 16px; background-position: 100% 37.5%; } @media all and (-ms-high-contrast: none), (-ms-high-contrast: active) { Romiplostim FDA approval was expanded once again on October 19, 2019, for the treatment of newly diagnosed or persistent ITP in adults who do not respond to treatment with corticosteroids, immunoglobulins, or splenectomy. /***********External popup********/ .text-material-flex .text-section { width: 60%; padding-left: 49px; } if (startTime) { Immune Thrombocytopenia (ITP) Treatment | Nplate (romiplostim) Nplate is a prescription medicine used to treat low blood platelet counts (thrombocytopenia) in: adults with immune thrombocytopenia (ITP) when certain medicines or surgery to remove your spleen have not worked well enough. Generic name: romiplostim Dosage form: injection, powder, lyophilized, for solution Drug class: Platelet-stimulating agents Medically reviewed by Drugs.com. var target = $(this).attr("id"); FDA Approves Nplate (Romiplostim) For Use In Pediatric - Amgen $(function () { p:empty { display: none; } .material-text { padding: 1rem; } // Create array for player IDs .material-text a.btn.btn-primary.read::after { content: ''; background-image: url(/-/media/project/agc_ie/icons/right-arrow-red.png); width: 26px; height: 20px; position: absolute; right: 1rem; background-repeat: no-repeat;} Your doctor may need to change the doses of your medications or monitor you carefully for side effects. @media (max-width:540px) { STEP 1: Input patient weight in kg or lbs kg lb STEP 2: Select Nplate dose mcg/kg STEP 3: Note total dose (mcg) and injection volume (mL) Patient's Total Dose -- Patient's Total Dose (mcg) = patient's weight (kg) x dose (mcg/kg) Injection Volume -- Injection Volume (mL) = patient's total dose 500 mcg/mL IndiaMART > Common Disease Medicines > Injectable Products > Romiplostim Injection > Mumbai. (18), Another clinical study that evaluated romiplostim efficacy and safety found that it took 10 to 14 days for the medication to reach the maximum effect on platelet count. It helps to prevent excessive loss of blood, stops bleeding and enhances the healing process. .material-type.nplate-type1 { min-height: 10rem;} /*********Media Quires***********/ acutalHeaderHeight -= $("#header_wrapper").parent().height(); footer a { font-size: 0.9rem; color: #fff; } .teaser-stage::after {position: absolute; left: 50%; width: 8rem; height: 5rem; background-image: url(/-/media/project/agc_ie/icons/light-pink-tip.png); bottom: -5rem; content: ''; display: block; background-repeat: no-repeat; background-size: 100%; transform: translate(-50%); } Side Effects of Nplate (Romiplostim), Warnings, Uses - RxList } NCI Dictionary of Cancer Terms: Nplate. Nplate (romiplostim) is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines . .patient-resources { background: #eaf6ff; position: relative;} .owl-dot.active { background: #0072ce;} var setPlayer = Object.keys(videojs.players)[x]; p+p { margin: 0; } @media (max-width:414px) { $(".repatha-link").css("z-index", "22"); Romiplostim injection is also used to treat acute radiation syndrome in patients who have been exposed to high levels (myelosuppressive doses) of radiation. @media (max-width:1024px) { } } #heading3{color:#fff;} var temp = document.createElement('div'); Romiplostim Medicare Coverage and Co-Pay Details - GoodRx .p.accor-ol { font-size: .9rem!important;} More specifically, romiplostim binds to the thrombopoietin receptor, which then helps promote the growth of cells in bone marrow that support and drive the higher production of blood platelets. Romiplostim injection should not be used to treat people who have low platelet levels caused by myelodysplastic syndrome (a group of conditions in which the bone marrow produces blood cells that are misshapen and does not produce enough healthy blood cells) or any other conditions that cause low platelet levels other than ITP. Some romiplostim side effects are more common than others. Romiplostim Injection - Prescriptiongiant right: 0; Romiplostim may be given by subcutaneous (the layer between the skin and muscle) injection. Pharmacology: Half-life of Drugs. { .material-img img { border-radius: 10px 10px 0 0;} FDA has concluded that establishing the long-term safety of Nplate and Promacta is best achieved through ongoing clinical trials, post-approval studies, and post-marketing adverse event reports. Romiplostim injection may cause changes in your bone marrow. Medicinal forms | Romiplostim | Drugs | BNF | NICE .banner-img { width: 40%; margin-left: auto; } temp.innerHTML = '' ; This cookie is set by GDPR Cookie Consent plugin. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administrations (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). h3.accordion_trigger--h3 {margin: 0.5rem 0 0;} @media (max-width: 375px){ August 2019. We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. August 2019. " ", Modified Risk Evaluation and Mitigation Strategies for Nplate .material-text a.btn.btn-primary.read { background: #fff; color: #ec951a; border-color: #ec951a; margin-bottom: 1rem; border-radius: 36px; min-height: auto; line-height: 1; text-transform: none; padding: 0.5rem 5rem 0.5rem 1.8rem; } Many other medications may also interact with romiplostim, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. responsive: { } catch (err) { .footer-top-txt .p { font-size: 0.9rem; } .home-img { padding: 1rem; } } console.log("Entered onPlay"); } else { var acutalHeaderHeight = $(".header").height(); }, .btn { min-height: auto; line-height: 1; } What are the side effects of Romiplostim? This increases the risk that you will experience bleeding problems. currentPopUp.show(); The NDC Code 55513-221-01 is assigned to a package of 1 vial in 1 carton > .5 ml in 1 vial of Nplate, a human prescription drug labeled by Amgen Inc. UPMC Hillman Cancer Center. Romiplostim injection comes as a powder to be mixed with liquid to be injected subcutaneously (under the skin) by a doctor or nurse in a medical office. } you have received training from your healthcare professional. NPLATE- romiplostim injection, powder, lyophilized, for solution - DailyMed (1, 4), Romiplostim injection can be administered in the outer part of the upper arm, the front of the middle thighs, or into a section of the abdomen located at least two inches away from the navel. @desc:To get the value of the query parameter of the URL, returns empty string if it is not there Nplate: Package Insert / Prescribing Information - Drugs.com .banner-title.kerning { letter-spacing: 1.5px; font-weight: bold;}
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